Seel St Hotel, managed by EPIC Hospitality Group, has opened its door this week.
The £20 million Ropewalks hotel has 128 rooms and a residents’ bar and gym.
It also boasts rooftop suites with terraces that provide unobstructed views across the city.
The new property is the latest phase in the £100 million transformation of Wolstenholme Square, which is linking the square to Seel Street from a new pedestrian passageway.
EPIC managing director, Simon Beer said: "We had more than one hundred and twenty supporters booked in from around the world and they returned to the hotel more than happy.
"We’re delighted to bring such a high quality product to the market, the design values, fit-out quality and service standards will redefine the luxury boutique sector in the city and early bookings are considerably ahead of forecast."
Elliot Lawless of Elliot Group says the investment will ‘add another dimension’ to his wider vision for Wolstenholme Square, he added: "This makes it a truly mixed-use scheme and completes the jigsaw puzzle.
"The property offers contemporary luxury and lots of nice design touches and sits really well in what is a very eclectic neighbourhood from an architectural standpoint."
EPIC is also working with Elliot Group on the delivery of their second Liverpool hotel, in the Baltic Triangle.
The £70m, 306 bedroom-property will also have views across Liverpool’s south docks to the Welsh mountains and will also offer guests a roof-top pool, spa and lounge.